diff --git a/README.md b/README.md
index 5d2838d..aecbfc9 100644
--- a/README.md
+++ b/README.md
@@ -95,7 +95,7 @@ catch (error) {
 Via CLI:
 
 ```sh
-replace-in-file from to some/file.js,some/**/glob.js
+replace-in-file from to some/file.js,some/**/glob.js [--isRegex]
 ```
 
 The options `allowEmptyPaths` and `encoding` are supported in the CLI.
@@ -103,6 +103,8 @@ In addition, the CLI supports the `verbose` option to list the changed files.
 
 Multiple files or globs can be replaced by providing a comma separated list.
 
+A regular expression may be used for the `from` parameter by specifying the `--isRegex` option.
+
 ## License
 (MIT License)
 
diff --git a/bin/cli.js b/bin/cli.js
index a5a99a5..0c7b06d 100755
--- a/bin/cli.js
+++ b/bin/cli.js
@@ -15,7 +15,7 @@ if (argv._.length < 3) {
 }
 
 //Collect main arguments
-const from = argv._.shift();
+let from = argv._.shift();
 const to = argv._.shift();
 
 //Single star globs already get expanded in the command line
@@ -23,6 +23,19 @@ const files = argv._.reduce((files, file) => {
   return files.concat(file.split(','));
 }, []);
 
+// If the --isRegex flag is passed, send the 'from' parameter
+// to the lib as a RegExp object
+if (argv.isRegex) {
+  const flags = from.replace(/.*\/([gimy]*)$/, '$1');
+  const pattern = from.replace(new RegExp(`^/(.*?)/${flags}$`), '$1');
+  try {
+    from = new RegExp(pattern, flags);
+  }
+  catch (error) {
+    console.error('Could not create RegExp from \'from\' parameter', error);
+  }
+}
+
 //Log
 console.log(`Replacing '${from}' with '${to}'`);