diff --git a/packages/react-native-web/src/exports/createElement/__tests__/__snapshots__/index-test.js.snap b/packages/react-native-web/src/exports/createElement/__tests__/__snapshots__/index-test.js.snap
index c86761eb..4b97c76d 100644
--- a/packages/react-native-web/src/exports/createElement/__tests__/__snapshots__/index-test.js.snap
+++ b/packages/react-native-web/src/exports/createElement/__tests__/__snapshots__/index-test.js.snap
@@ -1,6 +1,6 @@
 // Jest Snapshot v1, https://goo.gl/fbAQLP
 
-exports[`modules/createElement it normalizes event.nativeEvent 1`] = `
+exports[`modules/createElement normalizes event.nativeEvent 1`] = `
 Object {
   "_normalized": true,
   "bubbles": undefined,
@@ -23,6 +23,6 @@ Object {
 }
 `;
 
-exports[`modules/createElement it renders different DOM elements 1`] = `<span />`;
+exports[`modules/createElement renders different DOM elements 1`] = `<span />`;
 
-exports[`modules/createElement it renders different DOM elements 2`] = `<main />`;
+exports[`modules/createElement renders different DOM elements 2`] = `<main />`;
diff --git a/packages/react-native-web/src/exports/createElement/__tests__/index-test.js b/packages/react-native-web/src/exports/createElement/__tests__/index-test.js
index bf75e2a9..a4d5db0d 100644
--- a/packages/react-native-web/src/exports/createElement/__tests__/index-test.js
+++ b/packages/react-native-web/src/exports/createElement/__tests__/index-test.js
@@ -5,14 +5,14 @@ import React from 'react';
 import { render, shallow } from 'enzyme';
 
 describe('modules/createElement', () => {
-  test('it renders different DOM elements', () => {
+  test('renders different DOM elements', () => {
     let component = render(createElement('span'));
     expect(component).toMatchSnapshot();
     component = render(createElement('main'));
     expect(component).toMatchSnapshot();
   });
 
-  test('it normalizes event.nativeEvent', done => {
+  test('normalizes event.nativeEvent', done => {
     const onClick = e => {
       e.nativeEvent.timestamp = 1496876171255;
       expect(e.nativeEvent).toMatchSnapshot();
diff --git a/packages/react-native-web/src/exports/createElement/index.js b/packages/react-native-web/src/exports/createElement/index.js
index 0020bf05..32780318 100644
--- a/packages/react-native-web/src/exports/createElement/index.js
+++ b/packages/react-native-web/src/exports/createElement/index.js
@@ -20,6 +20,9 @@ EventPluginHub.injection.injectEventPluginsByName({
   ResponderEventPlugin
 });
 
+const isModifiedEvent = event =>
+  !!(event.metaKey || event.altKey || event.ctrlKey || event.shiftKey);
+
 /**
  * Ensure event handlers receive an event of the expected shape. The 'button'
  * role – for accessibility reasons and functional equivalence to the native
@@ -43,7 +46,9 @@ const eventHandlerNames = {
   onTouchStartCapture: true
 };
 const adjustProps = domProps => {
-  const isButtonRole = domProps.role === 'button';
+  const { onClick, onResponderRelease, role } = domProps;
+
+  const isButtonRole = role === 'button';
   const isDisabled = AccessibilityUtil.isDisabled(domProps);
 
   Object.keys(domProps).forEach(propName => {
@@ -62,9 +67,20 @@ const adjustProps = domProps => {
     }
   });
 
-  // Button role should trigger 'onClick' if SPACE or ENTER keys are pressed
+  // Cancel click events if the responder system is being used. Click events
+  // are not an expected part of the React Native API, and browsers dispatch
+  // click events that cannot otherwise be cancelled from preceding mouse
+  // events in the responder system.
+  if (onResponderRelease) {
+    domProps.onClick = function(e) {
+      if (!e.isDefaultPrevented() && !isModifiedEvent(e.nativeEvent) && !domProps.target) {
+        e.preventDefault();
+      }
+    };
+  }
+
+  // Button role should trigger 'onClick' if SPACE or ENTER keys are pressed.
   if (isButtonRole && !isDisabled) {
-    const { onClick } = domProps;
     domProps.onKeyPress = function(e) {
       if (!e.isDefaultPrevented() && (e.which === 13 || e.which === 32)) {
         e.preventDefault();